Showing pharmacokinetics for Daidzein metabolite after consumption of various sources Metabolism

Kano M., Takayanagi T., Harada K., Sawada S., Ishikawa F. (2006) Bioavailability of isoflavones after ingestion of soy beverages in healthy adults. J Nutr 136:2291-6 PubMed (16920843)

Plasma and Urine analysed after enzymatic deconjugation

Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 3 5 8 24
1 100 mL Single Dose 0 0.15 0.14 0.38 0.3 0
soy milk
2 100 mL Single Dose 0 0.82 0.35 0.55 0.38 0
fermented soy milk
3 100 mL Single Dose 0 0.97 0.4 0.45 0.35 0
enzyme-treated soy milk
L)&chxp=1,50|3,50&chd=t:0.0,1.0,3.0,5.0,8.0,24.0|0.0,0.15,0.14,0.38,0.3,0.0|0.0,1.0,4.0,5.0,8.0,24.0|0.0,0.82,0.35,0.55,0.38,0.0|0.0,1.0,4.0,5.0,8.0,24.0|0.0,0.97,0.4,0.45,0.35,0
Cumulative Excretion in Urine (µmol)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 2 6 12 24 48
1 100 mL Single Dose 0 1 6.5 12.5 15.5 17
soy milk
2 100 mL Single Dose 0 5 11 17 19 21
fermented soy milk
3 100 mL Single Dose 0 5 11 17 19 21
enzyme-treated soy milk
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