Showing pharmacokinetics for metabolites after consumption of Tea [green], powder in humans Metabolism

Meng X., Sang S., Zhu N., Lu H., Sheng S., Lee M.J., Ho C.T., Yang C.S. (2002) Identification and characterization of methylated and ring-fission metabolites of tea catechins formed in humans, mice, and rats. Chem Res Toxicol 15:1042-50 PubMed (12184788)

Plasma and Urine analysed after enzymatic deconjugation

Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 0.25 1 2 5 24
1 20 mg/kg bw Single Dose 0 60 140 150 75 20
(-)-Epigallocatechin 3-O-gallate
2 20 mg/kg bw Single Dose 0 5 20 22 10 0
4',4"-O-Dimethylepigallocatechin 3-O-gallate
L)&chxp=1,50|3,50&chd=t:0.0,0.25,1.0,2.0,5.0,24.0|0.0,60.0,140.0,150.0,75.0,20.0|0.0,0.25,1.0,2.0,5.0,24.0|0.0,5.0,20.0,22.0,10.0,0
Cumulative Excretion in Urine (µg)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 0 3 8
1 20 mg/kg bw Single Dose 0 10 30 55
(-)-Epigallocatechin 3-O-gallate
2 20 mg/kg bw Single Dose 0 60 180 325
4',4"-O-Dimethylepigallocatechin 3-O-gallate
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,8.08,1|2,0.0,328.25,20&chds=0.0,8.08,0.0,328.25,0.0,8.08,0.0,328.25&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(µg)&chxp=1,50|3,50&chd=t:0.0,0.0,3.0,8.0|0.0,10.0,30.0,55.0|0.0,0.0,3.0,8.0|0.0,60.0,180.0,325