Showing pharmacokinetics for metabolites after consumption of Juice mix in humans Metabolism

Ishii K., Furuta T., Kasuya Y. (2000) Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. J Agric Food Chem 48:56-9 PubMed (10637051)

Plasma and Urine analysed after enzymatic deconjugation

Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 2 4 6 24 48
1 6.3 mL/kg bw Single Dose 0 170 220 185 0 0
Naringenin
2 6.3 mL/kg bw Single Dose 0 25 132 150 0 0
Hesperetin
3 6.3 mL/kg bw Single Dose 0 85 125 120 0 0
Quercetin
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Cumulative Excretion in Urine (µg)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 3 6 12 24 48
1 6.3 mL/kg bw Single Dose 0 456 1846 2798 3076 3160
Naringenin
2 6.3 mL/kg bw Single Dose 0 103 905 1785 2221 2278
Hesperetin
3 6.3 mL/kg bw Single Dose 0 31 104 178 199 227
Quercetin
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