Showing pharmacokinetics for metabolites after consumption of Soy, powder, baked in humans Metabolism

Watanabe S., Yamaguchi M., Sobue T., Takahashi T., Miura T., Arai Y., Mazur W., Wahala K., Adlercreutz H. (1998) Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako). J Nutr 128:1710-5

Plasma and Urine analysed after enzymatic deconjugation

Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 6 8 12 24 72
1 60 g Single Dose 0 1.5 1.2 0.8 0.2 0
Daidzein
2 60 g Single Dose 0 2.4 2.1 1.8 0.8 0.1
Genistein
3 60 g Single Dose 0 0.03 0.3 0.35 0.1 0
Equol
4 60 g Single Dose 0 0.11 0.25 0.2 0.16 0
O-Desmethylangolensin
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Cumulative Excretion in Urine (µmol)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 6 12 24 48 72
1 60 g Single Dose 2.5 7.5 16 29 35 37
Daidzein
2 60 g Single Dose 0 3 7 24 18 19.7
Genistein
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