Showing pharmacokinetics for metabolites after consumption of Orange [Blond], juice in humans Metabolism
Franke A.A., Cooney R.V., Henning S.M., Custer L.J. (2005) Bioavailability and antioxidant effects of orange juice components in humans. J Agric Food Chem 53:5170-8 PubMed (15969493)
Plasma and Urine analysed after enzymatic deconjugation
Plasma Concentration (nmol/L) | |||||||
---|---|---|---|---|---|---|---|
Number | Dose | Multiple Dose Duration | Time (weeks) | Metabolite | |||
0 | 1 | 3 | |||||
1 | 236 mL/day | 22 days | 7.1 | 44 | 68.7 |
Naringenin
|
|
2 | 236 mL/day | 22 days | 3.3 | 34 | 21.6 |
Hesperetin
|
Excretion in Urine (nmol/mg creatinine) | |||||||
---|---|---|---|---|---|---|---|
Number | Dose | Multiple Dose Duration | Time (weeks) | Metabolite | |||
0 | 1 | 3 | |||||
1 | 236 mL/day | 22 days | 0.76 | 3.04 | 4.56 |
Naringenin
|
|
2 | 236 mL/day | 22 days | 0.49 | 10.29 | 7.84 |
Hesperetin
|