Showing pharmacokinetics for Daidzein metabolite after consumption of various sources Metabolism

Rufer C.E., Bub A., Moseneder J., Winterhalter P., Sturtz M., Kulling S.E. (2008) Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form: a randomized, double-blind, crossover study. Am J Clin Nutr 87:1314-23 PubMed (18469255)

Plasma and Urine analysed after enzymatic deconjugation

Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 3 6 12 24
1 1 capsule Single Dose 0 0 0.2 0.4 0.35 0
daidzein capsule
2 1 capsule Single Dose 0 0 1.1 1.8 2.5 1.8
daidzein-7-O-glucoside capsule
L)&chxp=1,50|3,50&chd=t:0.0,1.0,3.0,6.0,12.0,24.0|0.0,0.0,0.2,0.4,0.35,0.0|0.0,1.0,3.0,6.0,12.0,24.0|0.0,0.0,1.1,1.8,2.5,1
Cumulative Excretion in Urine (µmol)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 6 12 24
1 1 capsule Single Dose 0 4 19 31
daidzein capsule
2 1 capsule Single Dose 0 20 70 107
daidzein-7-O-glucoside capsule
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,24.240000000000002,2|2,0.0,108.07000000000001,10&chds=0.0,24.240000000000002,0.0,108.07000000000001,0.0,24.240000000000002,0.0,108.07000000000001&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(µmol)&chxp=1,50|3,50&chd=t:0.0,6.0,12.0,24.0|0.0,4.0,19.0,31.0|0.0,6.0,12.0,24.0|0.0,20.0,70.0,107