Showing pharmacokinetics for metabolites after consumption of Chocolate, dark in humans Metabolism
Rios L.Y., Gonthier M.P., Remesy C., Mila I., Lapierre C., Lazarus S.A., Williamson G., Scalbert A. (2003) Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects. Am J Clin Nutr 77:912-8 PubMed (12663291)
Urine analysed after enzymatic deconjugation
| Excretion in Urine (nmol/g creatinine) | |||||||
|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | |||
| 0 | 24 | 48 | |||||
| 1 | 80 g | Single Dose | 2943 | 974 | 887 |
Hippuric acid
|
|
| 2 | 80 g | Single Dose | 54.2 | 33.7 | 41.2 |
4-Hydroxybenzoic acid
|
|
| 3 | 80 g | Single Dose | 71.1 | 63.6 | 90.5 |
4-Hydroxyhippuric acid
|
|
| 4 | 80 g | Single Dose | 70.1 | 30.5 | 36.8 |
Phenylacetic acid
|
|
| 5 | 80 g | Single Dose | 3.1 | 2.6 | 2.4 |
Dihydrocaffeic acid
|
|