Rios L.Y., Gonthier M.P., Remesy C., Mila I., Lapierre C., Lazarus S.A., Williamson G., Scalbert A. (2003) Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects. Am J Clin Nutr 77:912-8 PubMed (12663291)

Urine analysed after enzymatic deconjugation

Excretion in Urine (nmol/g creatinine)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 3 6 9 24 48
1 80 g Single Dose 90 890 300 95 100 100
Vanillic acid
2 80 g Single Dose 18 17 19 31 60 40
3,4-Dihydroxyphenylacetic acid
3 80 g Single Dose 0 1 1 1 5 3
3-Hydroxybenzoic acid
4 80 g Single Dose 140 18 18 15 160 310
Ferulic acid
5 80 g Single Dose 25 15 15 20 50 160
3-Hydroxyphenylacetic acid
6 80 g Single Dose 5.5 2.5 2.75 3 10 13
3-Hydroxyphenylpropionic acid
G+creatinine)&chxp=1,50|3,50&chd=t:0.0,3.0,6.0,9.0,24.0,48.0|90.0,890.0,300.0,95.0,100.0,100.0|0.0,3.0,6.0,9.0,24.0,48.0|18.0,17.0,19.0,31.0,60.0,40.0|0.0,3.0,6.0,9.0,24.0,48.0|0.0,1.0,1.0,1.0,5.0,3.0|0.0,3.0,6.0,9.0,24.0,48.0|140.0,18.0,18.0,15.0,160.0,310.0|0.0,3.0,6.0,9.0,24.0,48.0|25.0,15.0,15.0,20.0,50.0,160.0|0.0,3.0,6.0,9.0,24.0,48.0|5.5,2.5,2.75,3.0,10.0,13