Showing pharmacokinetics for metabolites after consumption of Tea [green], powder in humans

Li C., Lee M.J., Sheng S., Meng X., Prabhu S., Winnik B., Huang B., Chung J.Y., Yan S., Ho C.T., Yang C.S. (2000) Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol 13:177-84 PubMed (10725114)

Plasma and Urine analysed after enzymatic deconjugation

Plasma Concentration (ng/mL)
Number	Dose	Multiple Dose Duration	Time (hours)						Metabolite
			0	3	5	8	12	24
1	20 mg/kg bw	Single Dose	0	12	30	23	24.5	5	5-(3',4',-dihydroxyphenyl)-γ-valerolactone
2	20 mg/kg bw	Single Dose	0	2.6	15.5	9.5	6.5	1	5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone

Ml)&chxp=1,50|3,50&chd=t:0.0,3.0,5.0,8.0,12.0,24.0|0.0,12.0,30.0,23.0,24.5,5.0|0.0,3.0,5.0,8.0,12.0,24.0|0.0,2.6,15.5,9.5,6.5,1

Cumulative Excretion in Urine (mg)
Number	Dose	Multiple Dose Duration	Time (hours)						Metabolite
			0	4.5	7.5	13.5	26	37
1	1.2 g	Single Dose	0	70	270	750	810	860	5-(3',4',-dihydroxyphenyl)-γ-valerolactone
2	1.2 g	Single Dose	0	58	388	1708	1858	1862	5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone

Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,37.37,2|2,0.0,1880.6200000000001,100&chds=0.0,37.37,0.0,1880.6200000000001,0.0,37.37,0.0,1880.6200000000001&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(mg)&chxp=1,50|3,50&chd=t:0.0,4.5,7.5,13.5,26.0,37.0|0.0,70.0,270.0,750.0,810.0,860.0|0.0,4.5,7.5,13.5,26.0,37.0|0.0,58.0,388.0,1708.0,1858.0,1862

Showing pharmacokinetics for metabolites after consumption of Tea [green], powder in humans Metabolism

Plasma and Urine analysed after enzymatic deconjugation