Showing pharmacokinetics for 5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone metabolite after consumption of Tea [green], powder in humans

Li C., Lee M.J., Sheng S., Meng X., Prabhu S., Winnik B., Huang B., Chung J.Y., Yan S., Ho C.T., Yang C.S. (2000) Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol 13:177-84 PubMed (10725114)

Plasma and Urine analysed after enzymatic deconjugation

Plasma Concentration (ng/mL)
Number	Dose	Multiple Dose Duration	Time (hours)						Polyphenol Source Name as described in publication
			0	3	5	8	12	24
1	20 mg/kg bw	Single Dose	0	2.6	15.5	9.5	6.5	1	green tea powder in hot water

Ml)&chxp=1,50|3,50&chd=t:0.0,3.0,5.0,8.0,12.0,24.0|0.0,2.6,15.5,9.5,6.5,1

Cumulative Excretion in Urine (µmol)
Number	Dose	Multiple Dose Duration	Time (days)						Polyphenol Source Name as described in publication
			0	4.5	7.5	13.5	26	37
1	1.2 g	Single Dose	0	58	388	1708	1858	1862	green tea powder in hot water

Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,37.37,2|2,0.0,1880.6200000000001,100&chds=0.0,37.37,0.0,1880.6200000000001,0.0,37.37,0.0,1880.6200000000001,0.0,37.37,0.0,1880.6200000000001&chxl=1:|time+after+ingestion+(days)&chtt=cumulative+excretion+in+urine+(µmol)&chxp=1,50|3,50&chd=t:0.0,4.5,7.5,13.5,26.0,37.0|0.0,58.0,388.0,1708.0,1858.0,1862.0|0.0,3.0,8.0,24.0|0.0,0.0,2.4,7.2|0.0,6.0|0.0,524

Showing pharmacokinetics for 5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone metabolite after consumption of Tea [green], powder in humans Metabolism

Plasma and Urine analysed after enzymatic deconjugation