Showing pharmacokinetics for metabolites after consumption of Tea [green], powder in humans Metabolism

Li C., Lee M.J., Sheng S., Meng X., Prabhu S., Winnik B., Huang B., Chung J.Y., Yan S., Ho C.T., Yang C.S. (2000) Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol 13:177-84 PubMed (10725114)

Plasma and Urine analysed after enzymatic deconjugation

Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 4.5 7.5 13.5 26 37
1 1.2 g Single Dose 0 70 270 750 810 860
5-(3',4',-dihydroxyphenyl)-γ-valerolactone
2 1.2 g Single Dose 0 58 388 1708 1858 1862
5-(3',4',5'-trihydroxyphenyl)-γ-valerolactone
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