Showing pharmacokinetics for metabolites after consumption of Perilla frutescens tablet in humans Metabolism

Baba S., Osakabe N., Natsume M., Yasuda A., Muto Y., Hiyoshi K., Takano H., Yoshikawa T., Terao J. (2005) Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans. Eur J Nutr 44:1-9 PubMed (15309457)

Urine analysed after enzymatic deconjugation

Excretion in Urine (%)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 6 24 32 48
1 1 tablet Single Dose 0 1.09 1.47 1.49 1.5
Rosmarinic acid
2 1 tablet Single Dose 0 2.07 2.75 2.86 2.86
3-O-Methylrosmarinic acid
3 1 tablet Single Dose 0 0.64 0.73 0.95 0.96
Ferulic acid
4 1 tablet Single Dose 0 0.96 0.96 0.96 0.96
Caffeic acid
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