Nielsen I.L., Chee W.S., Poulsen L., Offord-Cavin E., Rasmussen S.E., Frederiksen H., Enslen M., Barron D., Horcajada M.N., Williamson G. (2006) Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial. J Nutr 136:404-8 PubMed (16424119)

Plasma analysed after enzymatic deconjugation

Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 2 3 7 10
1 5 mL/kg bw Single Dose 0 0 0.12 0.12 0.3 0.12
orange juice
2 5 mL/kg bw Single Dose 0 2.6 0.9 0.25 0.3 0.12
orange juice treated with hesperidinase
3 5 mL/kg bw Single Dose 0 0 0.12 0.12 0.8 0.7
orange juice fortified with hesperidin
L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,3.0,7.0,10.0|0.0,0.0,0.12,0.12,0.3,0.12|0.0,0.5,1.0,3.0,7.0,10.0|0.0,2.6,0.9,0.25,0.3,0.12|0.0,1.0,2.0,3.0,7.0,10.0|0.0,0.0,0.12,0.12,0.8,0