Showing pharmacokinetics for Hesperetin metabolite after consumption of various sources Metabolism
Nielsen I.L., Chee W.S., Poulsen L., Offord-Cavin E., Rasmussen S.E., Frederiksen H., Enslen M., Barron D., Horcajada M.N., Williamson G. (2006) Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial. J Nutr 136:404-8 PubMed (16424119)
Plasma analysed after enzymatic deconjugation
| Plasma Concentration (µmol/L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) |
Polyphenol Source Name as described in publication |
|||||
| 0 | 1 | 2 | 3 | 7 | 10 | ||||
| 1 | 5 mL/kg bw | Single Dose | 0 | 0 | 0.12 | 0.12 | 0.3 | 0.12 |
orange juice
|
| 2 | 5 mL/kg bw | Single Dose | 0 | 2.6 | 0.9 | 0.25 | 0.3 | 0.12 |
orange juice treated with hesperidinase
|
| 3 | 5 mL/kg bw | Single Dose | 0 | 0 | 0.12 | 0.12 | 0.8 | 0.7 |
orange juice fortified with hesperidin
|