Showing pharmacokinetics for metabolites after consumption of Quercetin in humans Metabolism

Loke W.M., Jenner A.M., Proudfoot J.M., McKinley A.J., Hodgson J.M., Halliwell B., Croft K.D. (2009) A metabolite profiling approach to identify biomarkers of flavonoid intake in humans. J Nutr 139:2309-14 PubMed (19812218)

Urine analysed after enzymatic deconjugation

Excretion in Urine (nmol/mmol creatinine)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 5
1 200 mg Single Dose 41 59
3-O-Methylgallic acid
2 200 mg Single Dose 1374 4042
Benzoic acid
3 200 mg Single Dose 89 200
Dihydro-p-coumaric acid
4 200 mg Single Dose 48 70
Protocatechuic acid
5 200 mg Single Dose 174 252
Dihydrocaffeic acid
6 200 mg Single Dose 596 855
Vanillic acid
7 200 mg Single Dose 364 481
Ferulic acid
8 200 mg Single Dose 0.9 3
Quercetin
9 200 mg Single Dose 409 854
4-Ethylphenol
10 200 mg Single Dose 142 181
3-Phenylpropionic acid
11 200 mg Single Dose 357 945
Methoxyphenylacetic acid
12 200 mg Single Dose 94 446
4-Ethylbenzoic acid
Mmol+creatinine)&chxp=1,50|3,50&chd=t:0.0,5.0|41.0,59.0|0.0,5.0|1374.0,4042.0|0.0,5.0|89.0,200.0|0.0,5.0|48.0,70.0|0.0,5.0|174.0,252.0|0.0,5.0|596.0,855.0|0.0,5.0|364.0,481.0|0.0,5.0|0.9,3.0|0.0,5.0|409.0,854.0|0.0,5.0|142.0,181.0|0.0,5.0|357.0,945.0|0.0,5.0|94.0,446