Showing pharmacokinetics for metabolites after consumption of Chlorogenic acid in rats Metabolism
Gonthier M.P., Verny M.A., Besson C., Remesy C., Scalbert A. (2003) Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J Nutr 133:1853-9 PubMed (12771329)
Urine analysed after enzymatic deconjugation
| Cumulative Excretion in Urine (µmol) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (days) | Metabolite | ||||||
| 0 | 1 | 2 | 3 | 6 | 8 | |||||
| 1 | 250 µmol/day | 8 days | 0 | 3.5 | 6.5 | 8.9 | 14.1 | 16.1 |
5-Caffeoylquinic acid
|
|
| 2 | 250 µmol/day | 8 days | 0 | 0.4 | 0.72 | 1.02 | 1.87 | 2.28 |
Caffeic acid
|
|
| 3 | 250 µmol/day | 8 days | 0 | 0.1 | 0.22 | 0.35 | 0.54 | 0.64 |
Isoferulic acid
|
|
| 4 | 250 µmol/day | 8 days | 0 | 0.5 | 0.93 | 1.34 | 2.14 | 2.63 |
Ferulic acid
|
|
| 5 | 250 µmol/day | 8 days | 0 | 5 | 15 | 22 | 26 | 26 |
m-Coumaric acid
|
|
| 6 | 250 µmol/day | 8 days | 0 | 45 | 195 | 335 | 610 | 775 |
Hippuric acid
|
|
| 7 | 250 µmol/day | 8 days | 0 | 65 | 155 | 222.5 | 307.5 | 347.5 |
3-Hydroxyphenylpropionic acid
|
|
| 8 | 250 µmol/day | 8 days | 0 | 0.25 | 1 | 2 | 2.75 | 2.9 |
3-Hydroxybenzoic acid
|
|
| 9 | 250 µmol/day | 8 days | 0 | 1.7 | 2.3 | 2.55 | 3.2 | 3.45 |
Dihydrocaffeic acid
|
|
| 10 | 250 µmol/day | 8 days | 0 | 0.95 | 2.25 | 3.25 | 4.6 | 5.25 |
3-Hydroxyhippuric acid
|
|