Showing pharmacokinetics for metabolites after consumption of Catechin in rats Metabolism

Gonthier M.P., Cheynier V., Donovan J.L., Manach C., Morand C., Mila I., Lapierre C., Remesy C., Scalbert A. (2003) Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols. J Nutr 133:461-7

Urine analysed after enzymatic deconjugation

Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (days) Metabolite
0 1 2 4 6 8
1 0.5 g/100 g bw Single Dose 0 0.5 0.9 1.7 2.5 3.3
3'-O-Methylcatechin
2 0.12 g/100 g bw Single Dose 0 8 15.5 22.5 40.5 52.5
3'-O-Methylcatechin
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