Showing pharmacokinetics for metabolites after consumption of Olive, oil, extra virgin in rats Metabolism

Visioli F., Galli C., Grande S., Colonnelli K., Patelli C., Galli G., Caruso D. (2003) Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration. J Nutr 133:2612-5

Urine analysed after enzymatic deconjugation

Cumulative Excretion in Urine (µg)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 24
1 500 µL Single Dose 16.5 35.7
Hydroxytyrosol
2 500 µL Single Dose 8.1 17.2
Homovanillyl alcohol
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,24.240000000000002,2|2,0.0,36.057,2&chds=0.0,24.240000000000002,0.0,36.057,0.0,24.240000000000002,0.0,36.057&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(µg)&chxp=1,50|3,50&chd=t:0.0,24.0|16.5,35.7|0.0,24.0|8.1,17