Showing pharmacokinetics for metabolites after consumption of Coffee beverage [Instant] in rats Metabolism

Rechner A.R., Spencer J.P., Kuhnle G., Hahn U., Rice-Evans C.A. (2001) Novel biomarkers of the metabolism of caffeic acid derivatives in vivo. Free Radic Biol Med 30:1213-22

Urine analysed after enzymatic deconjugation

Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (minutes) Metabolite
0 110 240 320 600 1200
1 4 g Single Dose 0 0.44 0.53 0.97 1.98 3.24
Ferulic acid
2 4 g Single Dose 0 0.11 0.16 0.27 0.58 1.06
Isoferulic acid
3 4 g Single Dose 0 0.11 0.2 0.32 0.6 1.47
Vanillic acid
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