Showing pharmacokinetics for metabolites after consumption of Rosmarinic acid in rats Metabolism

Baba S., Osakabe N., Natsume M., Terao J. (2004) Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric aci. Life Sci 75:165-78 PubMed (15120569)

Urine analysed after enzymatic deconjugation

Cumulative Excretion in Urine (µg)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 8 18
1 50 mg/kg bw Single Dose 0 0 20
m-Coumaric acid
2 50 mg/kg bw Single Dose 0 0 45
Caffeic acid
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,18.18,1|2,0.0,45.45,2&chds=0.0,18.18,0.0,45.45,0.0,18.18,0.0,45.45&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(µg)&chxp=1,50|3,50&chd=t:0.0,8.0,18.0|0.0,0.0,20.0|0.0,8.0,18.0|0.0,0.0,45