Baba S., Osakabe N., Natsume M., Terao J. (2004) Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric aci. Life Sci 75:165-78 PubMed (15120569)

Urine analysed after enzymatic deconjugation

Cumulative Excretion in Urine (µg)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 8 18
1 50 mg/kg bw Single Dose 0 0 20
m-Coumaric acid
2 50 mg/kg bw Single Dose 0 0 45
Caffeic acid
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,18.18,1|2,0.0,45.45,2&chds=0.0,18.18,0.0,45.45,0.0,18.18,0.0,45.45&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(µg)&chxp=1,50|3,50&chd=t:0.0,8.0,18.0|0.0,0.0,20.0|0.0,8.0,18.0|0.0,0.0,45