Showing pharmacokinetics for metabolites after consumption of Sesaminol triglucoside in rats Metabolism

Jan K.C., Hwang L.S., Ho C.T. (2009) Tissue distribution and elimination of sesaminol triglucoside and its metabolites in rat. Mol Nutr Food Res 53:815-25 PubMed (20524667)

Plasma and Urine analysed after enzymatic deconjugation

Plasma Concentration (nmol/mL)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 1 3 6 9 24
1 1500 mg/kg bw 4 days 0 7 30 20 20 10
Sesaminol 2-O-triglucoside
2 1500 mg/kg bw 4 days 0 4 2 5 1 3
Sesaminol
Ml)&chxp=1,50|3,50&chd=t:0.0,1.0,3.0,6.0,9.0,24.0|0.0,7.0,30.0,20.0,20.0,10.0|0.0,1.0,3.0,6.0,9.0,24.0|0.0,4.0,2.0,5.0,1.0,3
Excretion in Urine (nmol/mL)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 2 6 10 14 20
1 500 mg/kg bw 4 days 0 187.3 146.7 207.8 108.8 18
Sesaminol 2-O-triglucoside
2 500 mg/kg bw 4 days 0 1.5 0.8 1.5 2.7 1.9
Sesaminol
Ml)&chxp=1,50|3,50&chd=t:0.0,2.0,6.0,10.0,14.0,20.0|0.0,187.3,146.7,207.8,108.8,18.0|0.0,2.0,6.0,10.0,14.0,20.0|0.0,1.5,0.8,1.5,2.7,1