Showing pharmacokinetics for p-Coumaric acid metabolite after consumption of Blackcurrant, juice in humans Metabolism

Rechner A.R., Kuhnle G., Hu H., Roedig-Penman A., van den Braak M.H., Moore K.P., Rice-Evans C.A. (2002) The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free Radic Res 36:1229-41

Plasma and Urine analysed without enzymatic deconjugation

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Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 2 4 6
1 330 mL Single Dose 0 37.2 27.1 9.5 3.3
blackcurrant juice
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Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (minutes) Polyphenol Source
Name as described in publication
0 45 100 200 460 700
1 330 mL Single Dose 0 0.04 0.16 0.24 0.33 0.33
blackcurrant juice
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