Showing pharmacokinetics for metabolites after consumption of Blackcurrant, juice in humans Metabolism
Rechner A.R., Kuhnle G., Hu H., Roedig-Penman A., van den Braak M.H., Moore K.P., Rice-Evans C.A. (2002) The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free Radic Res 36:1229-41
Plasma and Urine analysed without enzymatic deconjugation
Plasma Concentration (nmol/L) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | |||||
0 | 1 | 2 | 4 | 6 | |||||
1 | 330 mL | Single Dose | 0 | 6.1 | 1.1 | 0 | 0 |
Delphinidin 3-O-glucoside
|
|
2 | 330 mL | Single Dose | 0 | 51.3 | 29.3 | 10.1 | 1.4 |
Delphinidin 3-O-rutinoside
|
|
3 | 330 mL | Single Dose | 0 | 3.5 | 0.6 | 0 | 0 |
Cyanidin 3-O-glucoside
|
|
4 | 330 mL | Single Dose | 0 | 24.4 | 12.9 | 3.6 | 0 |
Cyanidin 3-O-rutinoside
|
|
5 | 330 mL | Single Dose | 0 | 9.8 | 6.5 | 0.5 | 0 |
Sinapic acid
|
|
6 | 330 mL | Single Dose | 0 | 37.2 | 27.1 | 9.5 | 3.3 |
p-Coumaric acid
|
|
7 | 330 mL | Single Dose | 0 | 122 | 115 | 52 | 28.9 |
Ferulic acid
|
|
8 | 330 mL | Single Dose | 0 | 73.9 | 75.6 | 27.5 | 10.6 |
Isoferulic acid
|
|
9 | 330 mL | Single Dose | 0 | 126 | 150 | 62.7 | 28 |
Vanillic acid
|
|
10 | 330 mL | Single Dose | 0.52 | 12.6 | 3.83 | 1.96 | 1.44 |
Hippuric acid
|
|
11 | 330 mL | Single Dose | 0 | 19 | 39 | 150 | 62 |
Quercetin
|
|
12 | 330 mL | Single Dose | 0 | 50 | 70 | 145 | 65 |
Kaempferol
|
Cumulative Excretion in Urine (mg) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Number | Dose | Multiple Dose Duration | Time (minutes) | Metabolite | ||||||
0 | 45 | 100 | 200 | 460 | 700 | |||||
1 | 330 mL | Single Dose | 0 | 0 | 0.03 | 0.11 | 0.15 | 0.15 |
Sinapic acid
|
|
2 | 330 mL | Single Dose | 0 | 0.04 | 0.16 | 0.24 | 0.33 | 0.33 |
p-Coumaric acid
|
|
3 | 330 mL | Single Dose | 0 | 0.04 | 0.22 | 0.35 | 0.45 | 0.45 |
Ferulic acid
|
|
4 | 330 mL | Single Dose | 0 | 0.04 | 0.18 | 0.26 | 0.3 | 0.3 |
Isoferulic acid
|
|
5 | 330 mL | Single Dose | 0 | 0.06 | 0.3 | 0.46 | 0.78 | 0.78 |
Vanillic acid
|