Showing pharmacokinetics for Sinapic acid metabolite after consumption of Blackcurrant, juice in humans Metabolism

Rechner A.R., Kuhnle G., Hu H., Roedig-Penman A., van den Braak M.H., Moore K.P., Rice-Evans C.A. (2002) The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free Radic Res 36:1229-41

Plasma and Urine analysed without enzymatic deconjugation

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Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 2 4 6
1 330 mL Single Dose 0 9.8 6.5 0.5 0
blackcurrant juice
L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,4.0,6.0|0.0,9.8,6.5,0.5,0
Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (minutes) Polyphenol Source
Name as described in publication
0 45 100 200 460 700
1 330 mL Single Dose 0 0 0.03 0.11 0.15 0.15
blackcurrant juice
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,707.0,100|2,0.0,0.1515,0.01515&chds=0.0,707.0,0.0,0.1515&chxl=1:|time+after+ingestion+(minutes)&chtt=cumulative+excretion+in+urine+(mg)&chxp=1,50|3,50&chd=t:0.0,45.0,100.0,200.0,460.0,700.0|0.0,0.0,0.03,0.11,0.15,0