Showing pharmacokinetics for metabolites after consumption of Blackcurrant, juice in humans Metabolism

Rechner A.R., Kuhnle G., Hu H., Roedig-Penman A., van den Braak M.H., Moore K.P., Rice-Evans C.A. (2002) The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free Radic Res 36:1229-41

Plasma analysed without enzymatic deconjugation

Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 1 2 4 6
1 330 mL Single Dose 0 6.1 1.1 0 0
Delphinidin 3-O-glucoside
2 330 mL Single Dose 0 51.3 29.3 10.1 1.4
Delphinidin 3-O-rutinoside
3 330 mL Single Dose 0 3.5 0.6 0 0
Cyanidin 3-O-glucoside
4 330 mL Single Dose 0 24.4 12.9 3.6 0
Cyanidin 3-O-rutinoside
5 330 mL Single Dose 0 9.8 6.5 0.5 0
Sinapic acid
6 330 mL Single Dose 0 37.2 27.1 9.5 3.3
p-Coumaric acid
7 330 mL Single Dose 0 122 115 52 28.9
Ferulic acid
8 330 mL Single Dose 0 73.9 75.6 27.5 10.6
Isoferulic acid
9 330 mL Single Dose 0 126 150 62.7 28
Vanillic acid
10 330 mL Single Dose 0.52 12.6 3.83 1.96 1.44
Hippuric acid
11 330 mL Single Dose 0 19 39 150 62
Quercetin
12 330 mL Single Dose 0 50 70 145 65
Kaempferol
L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,4.0,6.0|0.0,6.1,1.1,0.0,0.0|0.0,1.0,2.0,4.0,6.0|0.0,51.3,29.3,10.1,1.4|0.0,1.0,2.0,4.0,6.0|0.0,3.5,0.6,0.0,0.0|0.0,1.0,2.0,4.0,6.0|0.0,24.4,12.9,3.6,0.0|0.0,1.0,2.0,4.0,6.0|0.0,9.8,6.5,0.5,0.0|0.0,1.0,2.0,4.0,6.0|0.0,37.2,27.1,9.5,3.3|0.0,1.0,2.0,4.0,6.0|0.0,122.0,115.0,52.0,28.9|0.0,1.0,2.0,4.0,6.0|0.0,73.9,75.6,27.5,10.6|0.0,1.0,2.0,4.0,6.0|0.0,126.0,150.0,62.7,28.0|0.0,1.0,2.0,4.0,6.0|0.52,12.6,3.83,1.96,1.44|0.0,1.0,2.0,4.0,6.0|0.0,19.0,39.0,150.0,62.0|0.0,1.0,2.0,4.0,6.0|0.0,50.0,70.0,145.0,65