Showing pharmacokinetics for metabolites after consumption of Black raspberry, freeze-dried in humans Metabolism
Stoner G.D., Sardo C., Apseloff G., Mullet D., Wargo W., Pound V., Singh A., Sanders J., Aziz R., Casto B., Sun X. (2005) Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol 45:1153-1164 PubMed (16172180)
Plasma and Urine analysed without enzymatic deconjugation
| Plasma Concentration (ng/mL) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | ||||||
| 0 | 0.25 | 1 | 2 | 4 | 12 | |||||
| 1 | 45 g/day | 7 days | 1.5 | 1.6 | 2.8 | 2.8 | 1 | 0.8 |
Ellagic acid
|
|
| 2 | 45 g/day | 7 days | 0.1 | 0.5 | 2.2 | 1.5 | 0.5 | 0.1 |
Cyanidin 3-O-glucoside
|
|
| 3 | 45 g/day | 7 days | 0.1 | 0.35 | 1.8 | 1.8 | 1.3 | 0.5 |
Cyanidin 3-O-sambubioside
|
|
| 4 | 45 g/day | 7 days | 0 | 4 | 21 | 21 | 12 | 1 |
Cyanidin 3-O-rutinoside
|
|
| 5 | 45 g/day | 7 days | 0 | 1 | 5.5 | 6 | 5 | 1 |
Cyanidin 3-O-xylosyl-rutinoside
|
|
| Cumulative Excretion in Urine (µg) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | ||||
| 0 | 4 | 8 | 12 | |||||
| 1 | 45 g/day | 7 days | 1 | 9 | 12.3 | 13.3 |
Ellagic acid
|
|
| 2 | 45 g/day | 7 days | 0.8 | 15.8 | 19.8 | 21 |
Cyanidin 3-O-glucoside
|
|
| 3 | 45 g/day | 7 days | 0 | 19 | 34 | 44 |
Cyanidin 3-O-sambubioside
|
|
| 4 | 45 g/day | 7 days | 0 | 190 | 280 | 300 |
Cyanidin 3-O-rutinoside
|
|
| 5 | 45 g/day | 7 days | 0 | 60 | 114 | 131 |
Cyanidin 3-O-xylosyl-rutinoside
|
|