Showing pharmacokinetics for metabolites after consumption of Onion [Red], fried in humans Metabolism

Mullen W., Edwards C.A., Crozier A. (2006) Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Br J Nutr 96:107-16 PubMed (16869998)

Plasma and Urine analysed without enzymatic deconjugation

Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 0.5 1 2 3 6
1 270 g Single Dose 0 620 610 460 425 80
Quercetin 3'-sulfate
2 270 g Single Dose 0 300 225 120 110 80
Quercetin 3-O-glucuronide
3 270 g Single Dose 0 95 95 84 73 55
Isorhamnetin 3-O-glucuronide
L)&chxp=1,50|3,50&chd=t:0.0,0.5,1.0,2.0,3.0,6.0|0.0,620.0,610.0,460.0,425.0,80.0|0.0,0.5,1.0,2.0,3.0,6.0|0.0,300.0,225.0,120.0,110.0,80.0|0.0,0.5,1.0,2.0,3.0,6.0|0.0,95.0,95.0,84.0,73.0,55
Cumulative Excretion in Urine (nmol)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 4 8 24
1 270 g Single Dose 0 512 912 912
Quercetin 3-O-glucuronide
2 270 g Single Dose 0 979 1783 1845
Quercetin 3'-O-glucuronide
3 270 g Single Dose 0 767 1628 1789
Isorhamnetin 3-O-glucuronide
4 270 g Single Dose 0 451 700 700
Isorhamnetin 4'-O-glucuronide
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