Showing pharmacokinetics for metabolites after consumption of Coffee beverage [Instant] in humans Metabolism
Stalmach A., Mullen W., Barron D., Uchida K., Yokota T., Cavin C., Steiling H., Williamson G., Crozier A. (2009) Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption. Drug Metab Dispos 37:1749-58 PubMed (19460943)
Urine analysed without enzymatic deconjugation
| Cumulative Excretion in Urine (µmol) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | |||||
| 0 | 2 | 5 | 8 | 24 | |||||
| 1 | 200 mL | Single Dose | 0 | 0 | 0 | 0.4 | 0.7 |
Dihydrocaffeic acid 3-O-glucuronide
|
|
| 2 | 200 mL | Single Dose | 0 | 0.4 | 1.3 | 8.3 | 12.4 |
Dihydroferulic acid 4-sulfate
|
|
| 3 | 200 mL | Single Dose | 0 | 0.3 | 0.8 | 5.1 | 8.4 |
Dihydroferulic acid 4-O-glucuronide
|
|
| 4 | 200 mL | Single Dose | 0 | 0.1 | 0.2 | 0.3 | 0.4 |
Isoferulic acid 3-sulfate
|
|
| 5 | 200 mL | Single Dose | 0 | 1.2 | 1.9 | 3.4 | 4.8 |
Isoferulic acid 3-O-glucuronide
|
|
| 6 | 200 mL | Single Dose | 0 | 1.2 | 4.6 | 24.8 | 37.1 |
Dihydrocaffeic acid 3-sulfate
|
|
| 7 | 200 mL | Single Dose | 0 | 1.3 | 3.7 | 14 | 20.7 |
Feruloylglycine
|
|
| 8 | 200 mL | Single Dose | 0 | 1.8 | 3.1 | 4.8 | 6.4 |
Caffeic acid 3-sulfate
|
|
| 9 | 200 mL | Single Dose | 0 | 0.2 | 0.3 | 0.5 | 0.6 |
Caffeic acid 4-sulfate
|
|
| 10 | 200 mL | Single Dose | 0 | 1.8 | 2.9 | 6 | 11.1 |
Ferulic acid 4-sulfate
|
|
| 11 | 200 mL | Single Dose | 0 | 0.2 | 0.7 | 6.8 | 9.7 |
Dihydroferulic acid
|
|
| 12 | 200 mL | Single Dose | 0 | 0.7 | 1 | 1.2 | 1.2 |
3-Feruloylquinic acid
|
|
| 13 | 200 mL | Single Dose | 0 | 0.6 | 0.9 | 1.1 | 1.1 |
4-Feruloylquinic acid
|
|
| 14 | 200 mL | Single Dose | 0 | 0.5 | 0.7 | 0.9 | 1 |
5-Feruloylquinic acid
|
|