Showing pharmacokinetics for Dihydroferulic acid metabolite after consumption of Orange [Blond], pure juice, fortified with hesperidin in humans Metabolism

Roowi S., Mullen W., Edwards C.A., Crozier A. (2009) Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Mol Nutr Food Res 53 Suppl 1:S68-75 PubMed (19415668)

Urine analysed without enzymatic deconjugation

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Cumulative Excretion in Urine (µmol)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 2 5 10 24
1 250 mL Single Dose 0 0.1 1.1 3.9 6.2
orange juice fortified with hesperidin
2 250 mL Single Dose 0 0.2 0.2 0.2 2
orange juice fortified with hesperidin with 150 mL natural yoghurt
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