Showing pharmacokinetics for metabolites after consumption of Piceid in humans Metabolism
Burkon A., Somoza V. (2008) Quantification of free and protein-bound trans-resveratrol metabolites and identification of trans-resveratrol-C/O-conjugated diglucuronides - two novel resveratrol metabolites in human plasma. Mol Nutr Food Res 52:549-57 PubMed (18435437)
Plasma and Urine analysed without enzymatic deconjugation
| Plasma Concentration (µg/dL) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | ||||||
| 0 | 1 | 4 | 6 | 8 | 10 | |||||
| 1 | 85.5 mg/70 kg bw | Single Dose | 0 | 0.5 | 5 | 6.5 | 2 | 0 |
trans-Resveratrol 3-O-glucuronide
|
|
| 2 | 85.5 mg/70 kg bw | Single Dose | 0 | 0 | 5 | 7.7 | 4 | 0 |
trans-Resveratrol 4'-O-glucuronide
|
|
| 3 | 85.5 mg/70 kg bw | Single Dose | 0 | 29 | 25 | 21 | 10 | 6 |
trans-Resveratrol 3-sulfate
|
|
| 4 | 85.5 mg/70 kg bw | Single Dose | 0 | 4 | 8 | 12 | 6 | 12 |
trans-Resveratrol 3,4'-disulfate
|
|
| 5 | 85.5 mg/70 kg bw | Single Dose | 0 | 4 | 21 | 33 | 37 | 20 |
trans-Resveratrol 3,5-disulfate
|
|
| Cumulative Excretion in Urine (mg) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | ||||||
| 0 | 2 | 5 | 12 | 24 | 48 | |||||
| 1 | 85.5 mg/70 kg bw | Single Dose | 0 | 0.2 | 1.6 | 3.5 | 3.5 | 3.5 |
trans-Resveratrol 3-O-glucuronide
|
|
| 2 | 85.5 mg/70 kg bw | Single Dose | 0 | 0 | 0.2 | 1.9 | 1.9 | 1.9 |
trans-Resveratrol 4'-O-glucuronide
|
|
| 3 | 85.5 mg/70 kg bw | Single Dose | 0 | 0.8 | 3.3 | 5 | 5.35 | 5.35 |
trans-Resveratrol 3-sulfate
|
|
| 4 | 85.5 mg/70 kg bw | Single Dose | 0 | 0 | 0.5 | 1.6 | 1.85 | 1.85 |
trans-Resveratrol 3,4'-disulfate
|
|
| 5 | 85.5 mg/70 kg bw | Single Dose | 0 | 0.3 | 2.7 | 6.1 | 7.7 | 7.7 |
trans-Resveratrol 3,5-disulfate
|
|