Showing pharmacokinetics for trans-Resveratrol 4'-O-glucuronide metabolite after consumption of Piceid in humans Metabolism

Burkon A., Somoza V. (2008) Quantification of free and protein-bound trans-resveratrol metabolites and identification of trans-resveratrol-C/O-conjugated diglucuronides - two novel resveratrol metabolites in human plasma. Mol Nutr Food Res 52:549-57 PubMed (18435437)

Plasma and Urine analysed without enzymatic deconjugation

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Plasma Concentration (µg/dL)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 4 6 8 10
1 85.5 mg/70 kg bw Single Dose 0 0 5 7.7 4 0
piceid
Dl)&chxp=1,50|3,50&chd=t:0.0,1.0,4.0,6.0,8.0,10.0|0.0,0.0,5.0,7.7,4.0,0
Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 2 5 12 24 48
1 85.5 mg/70 kg bw Single Dose 0 0 0.2 1.9 1.9 1.9
piceid
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,48.480000000000004,2|2,0.0,1.9189999999999998,0.1919&chds=0.0,48.480000000000004,0.0,1.9189999999999998&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(mg)&chxp=1,50|3,50&chd=t:0.0,2.0,5.0,12.0,24.0,48.0|0.0,0.0,0.2,1.9,1.9,1