Burkon A., Somoza V. (2008) Quantification of free and protein-bound trans-resveratrol metabolites and identification of trans-resveratrol-C/O-conjugated diglucuronides - two novel resveratrol metabolites in human plasma. Mol Nutr Food Res 52:549-57 PubMed (18435437)

Plasma and Urine analysed without enzymatic deconjugation

Plasma Concentration (µg/dL)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 1 4 6 8 10
1 85.5 mg/70 kg bw Single Dose 0 0.5 5 6.5 2 0
trans-Resveratrol 3-O-glucuronide
2 85.5 mg/70 kg bw Single Dose 0 0 5 7.7 4 0
trans-Resveratrol 4'-O-glucuronide
3 85.5 mg/70 kg bw Single Dose 0 29 25 21 10 6
trans-Resveratrol 3-sulfate
4 85.5 mg/70 kg bw Single Dose 0 4 8 12 6 12
trans-Resveratrol 3,4'-disulfate
5 85.5 mg/70 kg bw Single Dose 0 4 21 33 37 20
trans-Resveratrol 3,5-disulfate
Dl)&chxp=1,50|3,50&chd=t:0.0,1.0,4.0,6.0,8.0,10.0|0.0,0.5,5.0,6.5,2.0,0.0|0.0,1.0,4.0,6.0,8.0,10.0|0.0,0.0,5.0,7.7,4.0,0.0|0.0,1.0,2.0,6.0,8.0,10.0|0.0,29.0,25.0,21.0,10.0,6.0|0.0,1.0,2.0,6.0,8.0,10.0|0.0,4.0,8.0,12.0,6.0,12.0|0.0,1.0,2.0,6.0,8.0,10.0|0.0,4.0,21.0,33.0,37.0,20
Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 2 5 12 24 48
1 85.5 mg/70 kg bw Single Dose 0 0.2 1.6 3.5 3.5 3.5
trans-Resveratrol 3-O-glucuronide
2 85.5 mg/70 kg bw Single Dose 0 0 0.2 1.9 1.9 1.9
trans-Resveratrol 4'-O-glucuronide
3 85.5 mg/70 kg bw Single Dose 0 0.8 3.3 5 5.35 5.35
trans-Resveratrol 3-sulfate
4 85.5 mg/70 kg bw Single Dose 0 0 0.5 1.6 1.85 1.85
trans-Resveratrol 3,4'-disulfate
5 85.5 mg/70 kg bw Single Dose 0 0.3 2.7 6.1 7.7 7.7
trans-Resveratrol 3,5-disulfate
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