Showing pharmacokinetics for metabolites after consumption of Beverage, polyphenol rich in humans Metabolism
Borges G., Mullen W., Mullan A., Lean M.E., Roberts S.A., Crozier A. (2010) Bioavailability of multiple components following acute ingestion of a polyphenol-rich juice drink. Mol Nutr Food Res 54 Suppl 2:S268-77 PubMed (20521274)
Urine analysed without enzymatic deconjugation
| Cumulative Excretion in Urine (µmol) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | |||||
| 0 | 2 | 5 | 8 | 24 | |||||
| 1 | 350 mL | Single Dose | 0 | 2 | 3.6 | 4.5 | 5 |
Epicatechin 3'-O-glucuronide
|
|
| 2 | 350 mL | Single Dose | 0 | 1.6 | 2.6 | 3.1 | 3.3 |
Phloretin 2'-O-glucuronide
|
|
| 3 | 350 mL | Single Dose | 0 | 0.03 | 0.2 | 0.4 | 0.4 |
Hesperetin 7-O-glucuronide
|
|
| 4 | 350 mL | Single Dose | 0 | 0.3 | 0.4 | 0.7 | 1.5 |
Caffeic acid 3-sulfate
|
|
| 5 | 350 mL | Single Dose | 0 | 0.3 | 0.6 | 2.4 | 5.9 |
Dihydrocaffeic acid 3-sulfate
|
|
| 6 | 350 mL | Single Dose | 0 | 0.3 | 0.5 | 1.4 | 3.6 |
Ferulic acid 4-sulfate
|
|
| 7 | 350 mL | Single Dose | 0 | 0.2 | 0.5 | 1 | 2 |
Dihydroferulic acid
|
|
| 8 | 350 mL | Single Dose | 0 | 0.08 | 0.18 | 0.38 | 0.68 |
Dihydroferulic acid 4-sulfate
|
|
| 9 | 350 mL | Single Dose | 0 | 0.6 | 1.1 | 2.2 | 6.3 |
Feruloylglycine
|
|