Showing pharmacokinetics for metabolites after consumption of Resveratrol in humans Metabolism

Boocock D.J., Faust G.E., Patel K.R., Schinas A.M., Brown V.A., Ducharme M.P., Booth T.D., Crowell J.A., Perloff M., Gescher A.J., Steward W.P., Brenner D.E. (2007) Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 16:1246-52 PubMed (17548692)

Urine analysed without enzymatic deconjugation

Cumulative Excretion in Urine (% of dose)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 2 4 8 12 24
1 0.5 g Single Dose 0 0.02 0.04 0.04 0.04 0.04
Resveratrol
2 0.5 g Single Dose 0 3.8 7.6 10.4 11.4 11.5
Resveratrol 3-sulfate
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,24.240000000000002,2|2,0.0,11.615,1&chds=0.0,24.240000000000002,0.0,11.615,0.0,24.240000000000002,0.0,11.615&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(%+of+dose)&chxp=1,50|3,50&chd=t:0.0,2.0,4.0,8.0,12.0,24.0|0.0,0.02,0.04,0.04,0.04,0.04|0.0,2.0,4.0,8.0,12.0,24.0|0.0,3.8,7.6,10.4,11.4,11