Showing pharmacokinetics for metabolites after consumption of Tomato, juice, enriched with rutin in humans Metabolism

Jaganath I.B., Mullen W., Edwards C.A., Crozier A. (2006) The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radic Res 40:1035-46 PubMed (17015248)

Plasma and Urine analysed without enzymatic deconjugation

Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 3 4 5 6 8
1 300 mL Single Dose 0 0 10 8.2 7.1 0
Quercetin 3-O-glucuronide
2 300 mL Single Dose 0 0 2.5 3.8 4 0.9
Isorhamnetin 3-O-glucuronide
L)&chxp=1,50|3,50&chd=t:0.0,3.0,4.0,5.0,6.0,8.0|0.0,0.0,10.0,8.2,7.1,0.0|0.0,3.0,4.0,5.0,6.0,8.0|0.0,0.0,2.5,3.8,4.0,0
Cumulative Excretion in Urine (nmol)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 5 8 24
1 300 mL Single Dose 0 216 249.6 270.5
Quercetin 3-O-glucuronide
2 300 mL Single Dose 0 105.5 145.5 179.16
Isorhamnetin 3-O-glucuronide
3 300 mL Single Dose 0 224.17 236.97 237
Quercetin 4'-O-glucuronide
4 300 mL Single Dose 0 202.33 213.83 219.7
Quercetin 3'-O-glucuronide
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,24.240000000000002,2|2,0.0,273.205,20&chds=0.0,24.240000000000002,0.0,273.205,0.0,24.240000000000002,0.0,273.205,0.0,24.240000000000002,0.0,273.205,0.0,24.240000000000002,0.0,273.205&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(nmol)&chxp=1,50|3,50&chd=t:0.0,5.0,8.0,24.0|0.0,216.0,249.6,270.5|0.0,5.0,8.0,24.0|0.0,105.5,145.5,179.16|0.0,5.0,8.0,24.0|0.0,224.17,236.97,237.0|0.0,5.0,8.0,24.0|0.0,202.33,213.83,219