Showing pharmacokinetics for Isorhamnetin 3-O-glucuronide metabolite after consumption of Tomato, juice, enriched with rutin in humans Metabolism

Jaganath I.B., Mullen W., Edwards C.A., Crozier A. (2006) The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radic Res 40:1035-46 PubMed (17015248)

Plasma and Urine analysed without enzymatic deconjugation

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Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 3 4 5 6 8
1 300 mL Single Dose 0 0 2.5 3.8 4 0.9
tomato juice enriched with rutin
L)&chxp=1,50|3,50&chd=t:0.0,3.0,4.0,5.0,6.0,8.0|0.0,0.0,2.5,3.8,4.0,0
Cumulative Excretion in Urine (nmol)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 5 8 24
1 300 mL Single Dose 0 105.5 145.5 179.16
tomato juice enriched with rutin
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,24.240000000000002,2|2,0.0,180.95159999999998,10&chds=0.0,24.240000000000002,0.0,180.95159999999998&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(nmol)&chxp=1,50|3,50&chd=t:0.0,5.0,8.0,24.0|0.0,105.5,145.5,179