Showing pharmacokinetics for metabolites after consumption of Anthocyanin, concentrate in rats Metabolism

Harada K., Kano M., Takayanagi T., Yamakawa O., Ishikawa F. (2004) Absorption of acylated anthocyanins in rats and humans after ingesting an extract of Ipomoea batatas purple sweet potato tuber. Biosci Biotechnol Biochem 68:1500-7 PubMed (15277754)

Plasma and Urine analysed without enzymatic deconjugation

Plasma Concentration (pmol/mL)
Number Dose Multiple Dose Duration Time (minutes) Metabolite
0 10 15 30 60 180
1 10 mL/kg bw Single Dose 0 9 5 2.5 2 0
Cyanidin 3-O-(2-O-(6-O-(E)-caffeoyl-D glucoside)-D-glucoside)-5-O-D-glucoside
2 10 mL/kg bw Single Dose 0 15 7.5 3 2 0
Peonidin 3-O-(2-O-(6-O-(E)-caffeoyl-D-glucosyl)-D-glucoside)-5-O-D-glucoside
Ml)&chxp=1,50|3,50&chd=t:0.0,10.0,15.0,30.0,60.0,180.0|0.0,9.0,5.0,2.5,2.0,0.0|0.0,10.0,15.0,30.0,60.0,180.0|0.0,15.0,7.5,3.0,2.0,0
Cumulative Excretion in Urine (nmol)
Number Dose Multiple Dose Duration Time (minutes) Metabolite
0 15 30 60 120 180
1 10 mL/kg bw Single Dose 0 3 9 16.5 27.5 36.5
Cyanidin 3-O-(2-O-(6-O-(E)-caffeoyl-D glucoside)-D-glucoside)-5-O-D-glucoside
2 10 mL/kg bw Single Dose 0 3 10 20 36 49
Peonidin 3-O-(2-O-(6-O-(E)-caffeoyl-D-glucosyl)-D-glucoside)-5-O-D-glucoside
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,181.8,10|2,0.0,49.49,2&chds=0.0,181.8,0.0,49.49,0.0,181.8,0.0,49.49&chxl=1:|time+after+ingestion+(minutes)&chtt=cumulative+excretion+in+urine+(nmol)&chxp=1,50|3,50&chd=t:0.0,15.0,30.0,60.0,120.0,180.0|0.0,3.0,9.0,16.5,27.5,36.5|0.0,15.0,30.0,60.0,120.0,180.0|0.0,3.0,10.0,20.0,36.0,49