Showing pharmacokinetics for (-)-Epicatechin metabolite after consumption of various sources Metabolism
Baba S., Osakabe N., Natsume M., Muto Y., Takizawa T., Terao J. (2001) Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats. J Agric Food Chem 49:6050-6 PubMed (25829765)
Plasma analysed without enzymatic deconjugation
| Plasma Concentration (µmol/L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) |
Polyphenol Source Name as described in publication |
|||||
| 0 | 1 | 2 | 4 | 8 | 18 | ||||
| 1 | 1 mg/kg bw | Single Dose | 0 | 0 | 0 | 0 | 0 | 0 |
(-)-epicatechin
|
| 2 | 5 mg/kg bw | Single Dose | 0 | 0.02 | 0 | 0 | 0 | 0 |
(-)-epicatechin
|
| 3 | 10 mg/kg bw | Single Dose | 0 | 0.25 | 0.04 | 0 | 0 | 0 |
(-)-epicatechin
|
| 4 | 150 mg/kg bw | Single Dose | 0 | 0.05 | 0 | 0 | 0 | 0 |
cocoa powder
|
| 5 | 750 mg/kg bw | Single Dose | 0 | 0.19 | 0.02 | 0 | 0 | 0 |
cocoa powder
|
| 6 | 1500 mg/kg bw | Single Dose | 0 | 0.34 | 0.19 | 0.03 | 0 | 0 |
cocoa powder
|