Showing pharmacokinetics for metabolites after consumption of Hesperidin in rats Metabolism
Matsumoto H., Ikoma Y., Sugiura M., Yano M., Hasegawa Y. (2004) Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma. J Agric Food Chem 52:6653-9 PubMed (15479036)
Plasma analysed without enzymatic deconjugation
| Plasma Concentration (µmol/L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | |||||
| 0 | 4 | 8 | 12 | 15 | |||||
| 1 | 50 mg/kg bw | Single Dose | 0 | 0.2 | 0.1 | 0.08 | 0 |
Hesperetin 7-O-glucuronide
|
|
| 2 | 50 mg/kg bw | Single Dose | 0 | 0.18 | 0.08 | 0.01 | 0 |
Hesperetin 3'-O-glucuronide
|
|