Showing pharmacokinetics for metabolites after consumption of Puerarin in rats Metabolism
Prasain J.K., Jones K., Brissie N., Moore R., Wyss J.M., Barnes S. (2004) Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry. J Agric Food Chem 52:3708-12 PubMed (15186086)
Urine analysed without enzymatic deconjugation
| Excretion in Urine (µmol/mL) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | ||||||
| 0 | 2 | 12 | 23.5 | 35 | 57.5 | |||||
| 1 | 50 mg/kg bw/3 days | 12 days | 0 | 0 | 0.0029 | 0.01 | 0.0029 | 0.0005 |
Daidzein
|
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| 2 | 50 mg/kg bw/3 days | 12 days | 0 | 0 | 0.004 | 0.02 | 0.0086 | 0.0004 |
Dihydrodaidzein
|
|
| 3 | 50 mg/kg bw/3 days | 12 days | 0 | 0 | 0.0001 | 0.02 | 0.04 | 0.01 |
Equol
|
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| 4 | 50 mg/kg bw/3 days | 12 days | 0 | 0 | 1.15 | 0.03 | 0.02 | 0.01 |
Puerarin
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