Showing pharmacokinetics for metabolites after consumption of Punicalagin in rats Metabolism

Cerda B., Llorach R., Ceron J.J., Espin J.C., Tomas-Barberan F.A. (2003) Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr 42:18-28 PubMed (12594538)

Plasma and Urine analysed without enzymatic deconjugation

Plasma Concentration (µg/mL)
Number Dose Multiple Dose Duration Time (days) Metabolite
0 7 14 21 29 37
1 6 % of diet 37 days 0 0.75 0.3 0.6 0.3 0.35
Ellagic acid
2 6 % of diet 37 days 0 29 28.5 28.5 28.5 29.5
Punicalagin
3 6 % of diet 37 days 0 0 0 1 3 6
Gallagic acid
Ml)&chxp=1,50|3,50&chd=t:0.0,7.0,14.0,21.0,29.0,37.0|0.0,0.75,0.3,0.6,0.3,0.35|0.0,7.0,14.0,21.0,29.0,37.0|0.0,29.0,28.5,28.5,28.5,29.5|0.0,7.0,14.0,21.0,29.0,37.0|0.0,0.0,0.0,1.0,3.0,6
Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (days) Metabolite
0 14 21 30 35 37
1 6 % of diet 37 days 0 0 1.6 3.15 3.9 4.5
Punicalagin
2 6 % of diet 37 days 0 0 1.2 2.65 3.3 3.9
Punicalin
3 6 % of diet 37 days 0 7 17 31 37.8 44.8
Urolithin A
4 6 % of diet 37 days 0 1.2 4 9.4 12.4 16.4
Urolithin C
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,37.37,2|2,0.0,45.248,2&chds=0.0,37.37,0.0,45.248,0.0,37.37,0.0,45.248,0.0,37.37,0.0,45.248,0.0,37.37,0.0,45.248&chxl=1:|time+after+ingestion+(days)&chtt=cumulative+excretion+in+urine+(mg)&chxp=1,50|3,50&chd=t:0.0,14.0,21.0,30.0,35.0,37.0|0.0,0.0,1.6,3.15,3.9,4.5|0.0,14.0,21.0,30.0,35.0,37.0|0.0,0.0,1.2,2.65,3.3,3.9|0.0,10.0,21.0,30.0,35.0,37.0|0.0,7.0,17.0,31.0,37.8,44.8|0.0,10.0,21.0,30.0,35.0,37.0|0.0,1.2,4.0,9.4,12.4,16