Showing pharmacokinetics for metabolites after consumption of Punicalagin in rats Metabolism

Cerda B., Llorach R., Ceron J.J., Espin J.C., Tomas-Barberan F.A. (2003) Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr 42:18-28 PubMed (12594538)

Urine analysed without enzymatic deconjugation

Cumulative Excretion in Urine (mg)
Number Dose Multiple Dose Duration Time (days) Metabolite
0 14 21 30 35 37
1 6 % of diet 37 days 0 0 1.6 3.15 3.9 4.5
Punicalagin
2 6 % of diet 37 days 0 0 1.2 2.65 3.3 3.9
Punicalin
3 6 % of diet 37 days 0 7 17 31 37.8 44.8
Urolithin A
4 6 % of diet 37 days 0 1.2 4 9.4 12.4 16.4
Urolithin C
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