Showing pharmacokinetics for metabolites after consumption of Red raspberry, pure juice in rats Metabolism

Borges G., Roowi S., Rouanet J.M., Duthie G.G., Lean M.E., Crozier A. (2007) The bioavailability of raspberry anthocyanins and ellagitannins in rats. Mol Nutr Food Res 51:714-25 PubMed (17533654)

Plasma and Urine analysed without enzymatic deconjugation

Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 1 3 6 12 24
1 2.77 mL Single Dose 0 0.3 0.4 0 0 0
Cyanidin 3-O-glucoside
2 2.77 mL Single Dose 0 16.4 8.2 5.8 0 0
Cyanidin 3-O-sophoroside
3 2.77 mL Single Dose 0 7.7 3.8 2 0 0
Pelargonidin 3-O-glucosyl-rutinoside
L)&chxp=1,50|3,50&chd=t:0.0,1.0,3.0,6.0,12.0,24.0|0.0,0.3,0.4,0.0,0.0,0.0|0.0,1.0,2.0,3.0,6.0,24.0|0.0,16.4,8.2,5.8,0.0,0.0|0.0,1.0,2.0,3.0,6.0,24.0|0.0,7.7,3.8,2.0,0.0,0
Cumulative Excretion in Urine (µmol)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 1 2 6 12 24
1 2.77 mL Single Dose 0 0.04 0.19 0.33 0.38 0.42
Cyanidin 3-O-glucoside
2 2.77 mL Single Dose 0 0.03 0.15 0.21 0.24 0.25
Cyanidin 3-O-rutinoside
3 2.77 mL Single Dose 0 0.44 2.83 4.58 5.39 5.75
Cyanidin 3-O-sophoroside
4 2.77 mL Single Dose 0 0.2 1.09 1.89 2.21 2.43
Pelargonidin 3-O-glucosyl-rutinoside
5 2.77 mL Single Dose 0 0 0.01 0.02 0.02 0.02
Cyanidin 3-O-xylosyl-rutinoside
6 2.77 mL Single Dose 0 0.02 0.17 0.3 0.31 0.31
Peonidin 3-O-glucoside
7 2.77 mL Single Dose 0 0.07 0.48 0.9 1.06 1.17
Peonidin 3-O-sophoroside
8 2.77 mL Single Dose 0 0.01 0.05 0.1 0.11 0.11
Pelargonidin 3-O-sophoroside
9 2.77 mL Single Dose 1.9 2.5 5.4 7.3 10.3 12.1
4-Hydroxyphenylacetic acid
10 2.77 mL Single Dose 6.9 7.2 14 24.7 35.7 45.4
Phenacetylglycine
11 2.77 mL Single Dose 0.2 0.3 1.3 1.7 1.7 1.7
Ferulic acid
Chart?cht=lxy&chs=600x300&chf=bg,s,fafafa&chxt=x,x,y&chxr=0,0.0,24.240000000000002,2|2,0.0,76.76,5&chds=0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76,0.0,24.240000000000002,0.0,76.76&chxl=1:|time+after+ingestion+(hours)&chtt=cumulative+excretion+in+urine+(µmol)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,6.0,12.0,24.0|0.0,0.04,0.19,0.33,0.38,0.42|0.0,1.0,2.0,6.0,12.0,24.0|0.0,0.03,0.15,0.21,0.24,0.25|0.0,1.0,2.0,6.0,12.0,24.0|0.0,0.44,2.83,4.58,5.39,5.75|0.0,1.0,2.0,6.0,12.0,24.0|0.0,0.2,1.09,1.89,2.21,2.43|0.0,1.0,2.0,6.0,12.0,24.0|0.0,0.0,0.01,0.02,0.02,0.02|0.0,1.0,2.0,6.0,12.0,24.0|0.0,0.02,0.17,0.3,0.31,0.31|0.0,1.0,2.0,6.0,12.0,24.0|0.0,0.07,0.48,0.9,1.06,1.17|0.0,1.0,2.0,6.0,12.0,24.0|0.0,0.01,0.05,0.1,0.11,0.11|0.0,1.0,2.0,6.0,12.0|20.7,20.9,35.1,44.3,76.0|0.0,1.0,2.0,6.0,12.0|0.6,0.6,0.6,0.7,1.9|0.0,1.0,2.0,6.0,12.0|0.2,0.4,1.2,1.5,2.0|0.0,1.0,2.0,6.0,12.0,24.0|1.9,2.5,5.4,7.3,10.3,12.1|0.0,1.0,2.0,6.0,12.0,24.0|6.9,7.2,14.0,24.7,35.7,45.4|0.0,1.0,2.0,6.0,12.0,24.0|0.2,0.3,1.3,1.7,1.7,1