Showing pharmacokinetics for Rosmarinic acid metabolite after consumption of Rosmarinic acid in rats Metabolism

Baba S., Osakabe N., Natsume M., Terao J. (2004) Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric aci. Life Sci 75:165-78 PubMed (15120569)

Plasma and Urine analysed without enzymatic deconjugation

Plasma Concentration (µmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 0.5 1 2 5 12
1 50 mg/kg bw Single Dose 0 0.62 0.25 0.1 0 0
rosmarinic acid in deoinized water
L)&chxp=1,50|3,50&chd=t:0.0,0.5,1.0,2.0,5.0,12.0|0.0,0.62,0.25,0.1,0.0,0
Cumulative Excretion in Urine (µg)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 8 18
1 50 mg/kg bw Single Dose 0 0 25
rosmarinic acid in deoinized water
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