Showing pharmacokinetics for metabolites after consumption of Cocoa, powder in humans Metabolism
Holt R.R., Lazarus S.A., Sullards M.C., Zhu Q.Y., Schramm D.D., Hammerstone J.F., Fraga C.G., Schmitz H.H., Keen C.L. (2002) Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr 76:798-804 PubMed (12324293)
Plasma analysed after enzymatic deconjugation
| Plasma Concentration (nmol/L) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) | Metabolite | ||||
| 0 | 0.5 | 2 | 6 | |||||
| 1 | 0.37 g/kg bw | Single Dose | 0 | 16 | 41 | 15 |
Procyanidin dimer B2
|
|
| 2 | 0.37 g/kg bw | Single Dose | 0.08 | 2.61 | 5.92 | 1.05 |
(-)-Epicatechin
|
|
| 3 | 0.37 g/kg bw | Single Dose | 0 | 0.13 | 0.16 | 0.02 |
(+)-Catechin
|
|