Showing pharmacokinetics for metabolites after consumption of Coffee beverage [Instant] in humans Metabolism

Guy P.A., Renouf M., Barron D., Cavin C., Dionisi F., Kochhar S., Rezzi S., Williamson G., Steiling H. (2009) Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 877:3965-74 PubMed (19879819)

Plasma analysed after enzymatic deconjugation

Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Metabolite
0 0.5 1.5 4 5 24
1 4 g Single Dose 0 50 70 30 35 5
Caffeic acid
2 4 g Single Dose 0 100 45 52 55 21
Isoferulic acid
3 4 g Single Dose 0 49 185 145 300 49
Dihydrocaffeic acid
4 4 g Single Dose 0 110 125 105 125 12
Ferulic acid
5 4 g Single Dose 0 180 500 450 1210 90
Dihydroferulic acid
L)&chxp=1,50|3,50&chd=t:0.0,0.5,1.5,4.0,5.0,24.0|0.0,50.0,70.0,30.0,35.0,5.0|0.0,1.0,4.0,5.0,8.0,24.0|0.0,100.0,45.0,52.0,55.0,21.0|0.0,0.5,2.0,4.0,8.0,24.0|0.0,49.0,185.0,145.0,300.0,49.0|0.0,0.5,1.0,2.0,6.0,24.0|0.0,110.0,125.0,105.0,125.0,12.0|0.0,1.0,2.0,3.0,8.0,24.0|0.0,180.0,500.0,450.0,1210.0,90