Showing pharmacokinetics for Protocatechuic acid metabolite after consumption of various sources Metabolism

Caccetta R.A., Croft K.D., Beilin L.J., Puddey I.B. (2000) Ingestion of red wine significantly increases plasma phenolic acid concentrations but does not acutely affect ex vivo lipoprotein oxidizability. Am J Clin Nutr 71:67-74

Plasma analysed after enzymatic deconjugation

Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 2 4
1 5 mL/kg bw Single Dose 110 98 98 90
red wine equivalents
2 5 mL/kg bw Single Dose 125 145 143 165
dealcoholized red wine equivalents
3 5 mL/kg bw Single Dose 120 100 100 115
phenol-stripped red wine equivalents
L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,4.0|110.0,98.0,98.0,90.0|0.0,1.0,2.0,4.0|125.0,145.0,143.0,165.0|0.0,1.0,2.0,4.0|120.0,100.0,100.0,115