Showing pharmacokinetics for Caffeic acid metabolite after consumption of various sources Metabolism

Caccetta R.A., Croft K.D., Beilin L.J., Puddey I.B. (2000) Ingestion of red wine significantly increases plasma phenolic acid concentrations but does not acutely affect ex vivo lipoprotein oxidizability. Am J Clin Nutr 71:67-74

Plasma analysed after enzymatic deconjugation

Plasma Concentration (nmol/L)
Number Dose Multiple Dose Duration Time (hours) Polyphenol Source
Name as described in publication
0 1 2 4
1 5 mL/kg bw Single Dose 37 55 85 45
red wine equivalents
2 5 mL/kg bw Single Dose 35 90 80 80
dealcoholized red wine equivalents
3 5 mL/kg bw Single Dose 27 25 22 22
phenol-stripped red wine equivalents
L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,4.0|37.0,55.0,85.0,45.0|0.0,1.0,2.0,4.0|35.0,90.0,80.0,80.0|0.0,1.0,2.0,4.0|27.0,25.0,22.0,22