Showing pharmacokinetics for metabolites after consumption of Flaxseed, meal in mice Metabolism

Kinniry P., Amrani Y., Vachani A., Solomides C.C., Arguiri E., Workman A., Carter J., Christofidou-Solomidou M. (2006) Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. J Nutr 136:1545-51 PubMed (22520446)

Plasma analysed after enzymatic deconjugation

Plasma Concentration (mg/L)
Number Dose Multiple Dose Duration Time (weeks) Metabolite
0 1 2 3 4 10
1 10 % of diet 10 weeks 0 0.49 0.24 0.23 0.28 0.13
Enterodiol
2 10 % of diet 10 weeks 0 0.16 0.09 0.11 0.22 0.12
Enterolactone
L)&chxp=1,50|3,50&chd=t:0.0,1.0,2.0,3.0,4.0,10.0|0.0,0.49,0.24,0.23,0.28,0.13|0.0,1.0,2.0,3.0,4.0,10.0|0.0,0.16,0.09,0.11,0.22,0