Showing pharmacokinetics for 3'-O-Methylepicatechin metabolite after consumption of Epicatechin in rats Metabolism
Baba S., Osakabe N., Natsume M., Muto Y., Takizawa T., Terao J. (2001) Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats. J Agric Food Chem 49:6050-6 PubMed (25829765)
Plasma analysed after enzymatic deconjugation
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| Plasma Concentration (µmol/L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number | Dose | Multiple Dose Duration | Time (hours) |
Polyphenol Source Name as described in publication |
|||||
| 0 | 1 | 2 | 4 | 8 | 18 | ||||
| 1 | 1 mg/kg bw | Single Dose | 0 | 1 | 0.74 | 0.73 | 0.3 | 0 |
(-)-epicatechin
|
| 2 | 5 mg/kg bw | Single Dose | 0 | 3.05 | 2.32 | 1.92 | 1.04 | 0 |
(-)-epicatechin
|
| 3 | 10 mg/kg bw | Single Dose | 0 | 4.5 | 3.51 | 1.83 | 0.7 | 0.03 |
(-)-epicatechin
|